Importance Osteoarthritis (OA) is the most common joint disease, affecting an estimated
more than 240 million people worldwide, including an estimated more than 32 million in the …

Cellular senescence is the inability of cells to proliferate, which has both beneficial and
detrimental effects on tissue development and homeostasis. Chronic accumulation of …

Osteoarthritis (OA) and posttraumatic OA (PTOA) are caused by an imbalance in catabolic
and anabolic processes in articular cartilage and proinflammatory changes throughout the …

Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is
one of the leading causes of chronic pain and is increasing in prevalence in accordance …

Objective Obesity was once considered a risk factor for knee osteoarthritis (OA) primarily for
biomechanical reasons. Here we provide an additional perspective by discussing how …

Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …

The prevalence of osteoarthritis (OA), a degenerative disorder of joints, has substantially
increased in recent years. Its key pathogenic hallmarks include articular cartilage …

Objectives As more has become known of the pathophysiology of osteoarthritis (OA),
evidence that inflammation plays a critical role in its development and progression has …

OBJECTIVES: To compare the effects of diagnostic labels and their explanations on
people's beliefs about managing hip pain. DESIGN: Online randomized controlled trial …

Molecular understanding of osteoarthritis (OA) has greatly increased over the past 15 years
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic '∼ …