Early-stage detection of leukemia is a critical determinant for successful treatment of the
disease and can increase the survival rate of leukemia patients. The factors limiting the …

Acute Myeloid Leukemia (AML) is the most common form of leukemia in adults with an
incidence of 4.3 per 100,000 cases per year. Historically, the identification of genetic …

Leukemia is a common malignant cancer of the hematopoietic system, whose pathogenesis
has not been fully elucidated. Long noncoding RNAs (lncRNAs) are transcripts longer than …

Simple Summary Research on leukemia has often led to novel approaches in clinical
practice. Cytogenetical and molecular markers have been introduced in treatment protocols …

The human transcriptome contains many non-coding RNAs (ncRNAs), which play important
roles in gene regulation. Long noncoding RNAs (lncRNAs) are an important class of …

The majority of the human genome is comprised of non-protein-coding genes, but the
relevance of non-coding RNAs in complex diseases has yet to be fully elucidated. One class …

Many patients with acute myeloid leukemia (AML) experience poor outcomes following
traditional high-dose chemotherapies and complete remission rates remain suboptimal …

Background High expression of immune checkpoints (ICs) and senescence molecules
(SMs) contributes to T cell dysfunction, tumor escape, and progression, but systematic …

Despite continuous improvements of AML therapy, the prognosis of AML patients remains
unsatisfactory. Recently, lncRNAs have been reported to participate in the development of …

Human endogenous retroviruses (HERVs) are LTR retrotransposons that are present in the
human genome. Among them, members of the HERV-K (HML-2) group are suspected to …