Exercise can prevent and improve the pathophysiology of diseases and promote healthy
aging. Thus, understanding the mechanisms that regulate the beneficial effects of exercise …

Skeletal muscle is a heterogeneous tissue comprised of fibers with different morphological,
functional, and metabolic properties. Different muscles contain varying proportions of fiber …

The interactions between nutrition and metabolism and skeletal muscle have long been
known. Muscle is the major metabolic organ—it consumes more calories than other organs …

Duchenne muscular dystrophy is a fatal X-linked genetic disease, caused by mutations in
the dystrophin gene, which cause functional loss of this protein. This pathology is associated …

Loss of muscle mass and function occurs in various diseases. Myostatin blocking can
attenuate muscle loss, but downstream signaling is not well known. Therefore, to elucidate …

Exercise training has been minimally explored as a therapy to mitigate the loss of muscle
strength for individuals with Duchenne muscular dystrophy (DMD). Voluntary wheel running …

The primary objective of this study was to determine whether alterations in mitochondria
affect recovery of skeletal muscle strength and mitochondrial enzyme activity following …

Previous genetic association studies of physical activity, in both animal and human models,
have been limited in number of subjects and genetically homozygous strains used as well …

Menopause is associated with declines in physical activity and skeletal muscle strength.
Physical activity is also reduced in rodents after ovariectomy (OVX) and whole-body …

Purpose We tested the hypothesis that low intensity exercise in mdx mice improves
plantarflexor muscle contractile function, resistance to fatigue, and mitochondrial …