Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

Mitochondrial morphological and ultrastructural changes occur during apoptosis and
autophagy, but whether they are relevant in vivo for tissue response to damage is unclear …

Obesity, diabetes, and metabolic syndrome result from complex interactions between
genetic and environmental factors, including the gut microbiota. To dissect these …

The ability of mammals to resist body fat accumulation is linked to their ability to expand the
number and activity of “brown adipocytes” within white fat depots. Activation of β-adrenergic …

We present a consolidated view of the complexity and challenges of designing studies for
measurement of energy metabolism in mouse models, including a practical guide to the …

Diet, genetics, and the gut microbiome are determinants of metabolic status, in part through
production of metabolites by the gut microbiota. To understand the mechanisms linking …

Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and
hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these …

Aims/hypothesis Metabolic disorders are commonly investigated using knockout and
transgenic mouse models. A variety of mouse strains have been used for this purpose …

White and brown adipocytes are believed to occupy different sites in the body. We studied
the anatomical features and quantitative histology of the fat depots in obesity and type 2 …