Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Objective Fenebrutinib (GDC‐0853) is a noncovalent, oral, and highly selective inhibitor of
Bruton's tyrosine kinase (BTK). The efficacy, safety, and pharmacodynamics of fenebrutinib …

Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

Transcriptomic analysis plays a key role in biomedical research. Linear dimensionality
reduction methods, especially principal-component analysis (PCA), are widely used in …

Abstract Machine learning (ML) is a computerized analytical technique that is being
increasingly employed in biomedicine. ML often provides an advantage over explicitly …

Artificial intelligence (AI)-based predictive models are being used to foster a precision
medicine approach to treat complex chronic diseases such as autoimmune and …

Systemic lupus erythematosus (SLE) is a complex and heterogeneous systemic
autoimmune disease associated with innate and adaptive immune dysregulation. SLE …

Abstract Objectives Systemic Lupus Erythematosus is a complex autoimmune disease that
leads to significant worsening of quality of life and mortality. Flares appear unpredictably …

Gene expression signatures can stratify patients with heterogeneous diseases, such as
systemic lupus erythematosus (SLE), yet understanding the contributions of ancestral …