Complement factor C5a is an integral constituent of the complement cascade critically
involved in the innate immune response, and it exerts its functions via two distinct receptors …

Chemokines are chemotactic cytokines that direct the traffic of leukocytes and other cells in
the body. Chemokines bind to G protein–coupled receptors expressed on target cells to …

CCL13/MCP-4 belongs to the CC chemokine family, which induces chemotaxis in many
immune cells. Despite extensive research into its function in numerous disorders, a thorough …

Significance: Efficient recruitment of neutrophils to an injured skin lesion is an important
innate immune response for wound repair. Defects in neutrophil recruitment lead to impaired …

CCRL2 is a seven-transmembrane domain receptor that belongs to the chemokine receptor
family. At difference from other members of this family, CCRL2 does not promote chemotaxis …

Simple Summary Various immune cells are involved in host immune responses to cancer. T-
helper (Th) 1 cells, cytotoxic CD8+ T cells, and natural killer cells are the major effector cells …

Background Natural killer (NK) cells have a unique capability of spontaneous cytotoxicity
against malignant cells and hold promise for off-the-shelf cell therapy against cancer. One of …

Diabetic retinopathy (DR) is considered as a diabetes-related complication that can render
severe visual impairments and is also a risk factor for acquired blindness in both developed …

Populations of CD8+ lung-resident memory T (TRM) cells persist in the interstitium and
epithelium (airways) following recovery from respiratory virus infections. While it is clear that …

Highlights•Chemotactic factors released in tumor microenvironment shape leukocyte
recruitment.•Tumor infiltrate can drive both pro-and anti-tumor activities.•Tumor infiltrating …