Gene therapy holds great promise for treating a multitude of inherited and acquired diseases
by delivering functional genes, comprising DNA or RNA, into targeted cells or tissues to elicit …

Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …

Nanoparticles (NPs), owing to their ultrasmall size, have been extensively researched for
potential applications in biomedicine. During their delivery and functionalization within the …

The past decades have seen significant research effort in the field of polymers for a range of
biomedical applications, driven by the promising prospect of these materials for realizing …

In this review, we outline the growing role that molecular dynamics simulation is able to play
as a design tool in drug delivery. We cover both the pharmaceutical and computational …

Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of
peptide drugs is a promising strategy for diabetes mellitus because of its convenience and …

Nanocarriers play an important role in drug delivery for disease treatment. However,
nanocarriers face a series of physiological barriers after administration such as blood …

The use of methods at molecular scale for the discovery of new potential active ligands, as
well as previously unknown binding sites for target proteins, is now an established reality …

Nintedanib (BIBF) is a biopharmaceutical classification system II (BCS II) drug that has a
good therapeutic effect for the treatment of nonsmall cell lung cancer; however, it shows …

Poly (β-amino ester) s (PAEs) have been widely developed for gene delivery, and
hydrophobic modification can further enhance their gene transfection efficiency. However …