The diffuse neuroendocrine system consists of specialised endocrine cells and peptidergic
nerves and is present in all organs of the body. Substance P (SP) is secreted by nerves and …

Release of neuropeptides, including tachykinins and calcitonin gene-related peptide, from
sensory nerves via an axon or local reflex may have inflammatory effects in the airways. This …

Bronchial hyperresponsiveness (BHR), an abnormal increase in airflow limitation following
the exposure to a stimulus, is an important pathophysiological characteristic of bronchial …

As chemical messengers, neuropeptides help to regulate all body functions and may reach
their target cells by one or more means (282): 1) as neurohormones, ie, neuroendocrine …

Recent reports suggest the involvement of vascular phenomena in exercise-induced
asthma. Sensory neuropeptides, such as substance P (SP), which causes airway vascular …

Airflow-induced bronchoconstriction (AIB) in mammals can be broadly categorized as either
vagal-dependent or vagal-independent. Among mammals, rabbits and cats belong to the …

Isocapnic dry gas hyperventilation provokes hyperpnea-induced bronchoconstriction in
guinea pigs by releasing tachykinins from airway sensory C-fiber neurons. It is unknown …

ABSTRACT LY303870[(R)-1-[N-(2-methoxybenzyl) acetylamino]-3-(1 H-in-dol-3-yl)-2-[N-(2-
(4-(piperidin-1-yI) piperidin-l-yI) acetyl) amino]-propane] is a new, potent and selective …

This study was performed to test the hypothesis that activated eosinophils or their secretory
products can directly stimulate sensory neurons to release their neuropeptides. Neurons …

Experiments were performed to characterize the pharmacology of SCH 206272 [(R, R)-1′[5-
[(3, 5-dichlorobenzoyl) methylamino]-3-(3, 4-dichlorophenyl)-4 (Z)-(methoxyimino) pentyl]-N …