Tachykinin NK2 antagonist for treatments of various disease states
Tachykinin NK 2 receptors are distributed in periphery, in the smooth muscle of the
respiratory, gastrointestinal, genitourinary tract, and within the brain. Substance P (SP) …
respiratory, gastrointestinal, genitourinary tract, and within the brain. Substance P (SP) …
Cold air-induced bronchoconstriction is mediated by tachykinin and kinin release in guinea pigs
S Yoshihara, P Geppetti, M Hara, A Lindén… - European journal of …, 1996 - Elsevier
In the present study, we investigated the role of acetylcholine, tachykinins and kinins in the
bronchoconstriction induced by cold air inhalation. Cold air was delivered to anaesthetised …
bronchoconstriction induced by cold air inhalation. Cold air was delivered to anaesthetised …
Mediators in hyperpnea-induced bronchoconstriction of guinea pigs
YL Lai, SP Lee - Naunyn-Schmiedeberg's archives of pharmacology, 1999 - Springer
Both tachykinins and leukotrienes (LTs) have been demonstrated to be the mediators for
hyperpnea-induced bronchoconstriction (HIB) of guinea pigs. We tested the hypothesis that …
hyperpnea-induced bronchoconstriction (HIB) of guinea pigs. We tested the hypothesis that …
Neurokinins modulate hyperventilation-induced bronchoconstriction in canine peripheral airways
AN Freed, S McCulloch, T Meyers… - American journal of …, 2003 - atsjournals.org
This study was designed to test the hypotheses that (1) neurokinin (NK) receptor activity
modulates hyperventilation-induced bronchoconstriction (HIB) in canine peripheral airways …
modulates hyperventilation-induced bronchoconstriction (HIB) in canine peripheral airways …
Hyperpnea-induced bronchoconstriction is dependent on tachykinin-induced cysteinyl leukotriene synthesis
XX Yang, WS Powell, M Hojo… - Journal of Applied …, 1997 - journals.physiology.org
Yang, XX, WS Powell, M. Hojo, and JG Martin. Hyperpnea-induced bronchoconstriction is
dependent on tachykinin-induced cysteinyl leukotriene synthesis. J. Appl. Physiol. 82 (2) …
dependent on tachykinin-induced cysteinyl leukotriene synthesis. J. Appl. Physiol. 82 (2) …
Tachykinins in the lungs.
RW Chapman, JA Hey, R McLeod… - Drug News & …, 1998 - europepmc.org
Tachykinins are neuropeptides which regulate various biological responses, some of which
are potentially important in the pathogenesis of pulmonary diseases such as asthma …
are potentially important in the pathogenesis of pulmonary diseases such as asthma …
Endogenous nitric oxide inhibits bronchoconstriction induced by cold-air inhalation in guinea pigs: role of kinins
S Yoshihara, JA Nadel, M Figini… - American journal of …, 1998 - atsjournals.org
Inhalation of cold air in guinea pigs increases total pulmonary resistance (Rl), an effect that
is mediated by kinins and tachykinins. Bronchoconstriction induced by bradykinin (BK) …
is mediated by kinins and tachykinins. Bronchoconstriction induced by bradykinin (BK) …
Exercise and airway physiology: interactions with immune and allergic responses
P Palange, V Brusasco, L Delgado… - European Respiratory …, 2005 - books.google.com
CO bicarbonate 2 produced component by the working of lactate muscles, isocapnic
because buffering. additional At higher CO2 is work generated loads, a from further the …
because buffering. additional At higher CO2 is work generated loads, a from further the …
β2-Adrenoceptor Agonist-Induced Upregulation of Tachykinin NK2 Receptor Expression and Function in Airway Smooth Muscle
T Katsunuma, AF Roffel, CRS Elzinga… - American journal of …, 1999 - atsjournals.org
Neurokinin A (NKA) induces bronchoconstriction mediated by tachykinin NK2 receptors in
animals and humans, and may be increased in asthma. Because β2-adrenoceptor agonists …
animals and humans, and may be increased in asthma. Because β2-adrenoceptor agonists …
Glucocorticoids reduce tachykinin NK2 receptor expression in bovine tracheal smooth muscle
T Katsunuma, JCW Mak, PJ Barnes - European journal of pharmacology, 1998 - Elsevier
Neurokinin A is not only a potent bronchoconstrictor, but also has immuno-modulatory
effects in animals and man, mediated via tachykinin NK2 receptors. We have examined the …
effects in animals and man, mediated via tachykinin NK2 receptors. We have examined the …