Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

A compelling long-term goal of cancer biology is to understand the crucial players during
tumorigenesis in order to develop new interventions. Here, we review how the four non …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

Introduction Acute kidney injury (AKI) can evolve quickly and clinical measures of function
often fail to detect AKI at a time when interventions are likely to provide benefit. Identifying …

Tissue inhibitors of metalloproteinases (TIMPs) are widely distributed in the animal kingdom
and the human genome contains four paralogous genes encoding TIMPs 1 to 4. TIMPs were …

Cells adhere to one another and/or to matrices that surround them. Regulation of cell–cell
(intercellular) and cell–matrix adhesion is tightly controlled in normal cells, however, defects …

Here we provide a protocol for quantitative three-dimensional ex vivo mouse aortic ring
angiogenesis assays, in which developing microvessels undergo many key features of …

As their name implies, matrix metalloproteinases are thought to be responsible for the
turnover and degradation of the extracellular matrix. However, matrix degradation is neither …

The matrix metalloproteinase (MMP) family of enzymes is comprised of critically important
extracellular matrix remodeling proteases whose activity has been implicated in a number of …