Targeting epigenetic regulators to overcome drug resistance in cancers
N Wang, T Ma, B Yu - Signal transduction and targeted therapy, 2023 - nature.com
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …
regulation is a heritable change in gene expressions independent of nucleotide sequence …
Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma
A Elmusrati, J Wang, CY Wang - International journal of oral science, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …
characterized by high morbidity and low survival rates with limited therapeutic options …
The influence of cell cycle regulation on chemotherapy
Y Sun, Y Liu, X Ma, H Hu - International journal of molecular sciences, 2021 - mdpi.com
Cell cycle regulation is orchestrated by a complex network of interactions between proteins,
enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation …
enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation …
Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
As a phenolic acid compound, caffeic acid (CA) can be isolated from different sources such
as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative …
as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative …
Drug resistance in cancer: mechanisms and tackling strategies
Drug resistance developed towards conventional therapy is one of the important reasons for
chemotherapy failure in cancer. The various underlying mechanism for drug resistance …
chemotherapy failure in cancer. The various underlying mechanism for drug resistance …
Drug resistance in cancer therapy: the Pandora's Box of cancer stem cells
H Rezayatmand, M Razmkhah… - Stem cell research & …, 2022 - Springer
Drug resistance is the main culprit of failure in cancer therapy that may lead to cancer
relapse. This resistance mostly originates from rare, but impactful presence of cancer stem …
relapse. This resistance mostly originates from rare, but impactful presence of cancer stem …
Mechanisms of acquired tumor drug resistance
SN Aleksakhina, A Kashyap, EN Imyanitov - Biochimica et Biophysica Acta …, 2019 - Elsevier
Systemic therapy often results in the reduction of tumor size but rarely succeeds in
eradicating all cancer cells. Drug efflux, persistence of cancer stem cells (CSCs), epithelial …
eradicating all cancer cells. Drug efflux, persistence of cancer stem cells (CSCs), epithelial …
Stem cell plasticity and dormancy in the development of cancer therapy resistance
ML De Angelis, F Francescangeli, F La Torre… - Frontiers in …, 2019 - frontiersin.org
Cancer treatment with either standard chemotherapy or targeted agents often results in the
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …
Colon cancer therapy by focusing on colon cancer stem cells and their tumor microenvironment
Despite many advances and optimization in colon cancer treatment, tumor recurrence and
metastases make the development of new therapies necessary. Colon cancer stem cells …
metastases make the development of new therapies necessary. Colon cancer stem cells …
Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer
Although many drugs/treatments are now available for most diseases, too often, resistance
to these treatments impedes complete therapeutic success. Acquired resistance is a major …
to these treatments impedes complete therapeutic success. Acquired resistance is a major …