Gonadal steroid feedback regulates the brain's patterned secretion of gonadotropin-
releasing hormone (GnRH). Negative feedback, which occurs in males and during the …

The mechanisms underlying the homeostatic estrogen negative feedback pathway central to
mammalian fertility have remained unresolved. Direct measurement of gonadotropin …

Fertility in mammals is ultimately controlled by a small population of neurons–the
gonadotropin-releasing hormone (GnRH) neurons–located in the ventral forebrain. GnRH …

The mechanism by which arcuate kisspeptin (ARNKISS) neurons co-expressing glutamate,
neurokinin B, and dynorphin intermittently synchronize their activity to drive pulsatile …

Background The neuroendocrine control of ovulation is orchestrated by neuronal circuits
that ultimately drive the release of gonadotropin-releasing hormone (GnRH) from the …

Epilepsy, a prevalent neurological disorder characterized by high morbidity, frequent
recurrence, and potential drug resistance, profoundly affects millions of people globally …

Kisspeptins are essential for the maturation of the hypothalamic-pituitary-gonadal (HPG)
axis and fertility. Hypothalamic kisspeptin neurons located in the anteroventral …

The mechanism by which arcuate kisspeptin (ARNKISS) neurons co-expressing glutamate,
neurokinin B, and dynorphin intermittently synchronize their activity to drive pulsatile …

Anovulation is a common presentation of infertility, yet in many cases the root cause is
unknown. This is, in part, due to an incomplete understanding of how ovarian estradiol …

Kisspeptins are a family of peptides that have been studied extensively during the past
years. Initially, they were known as metastatic suppressors, while now they are known for …