Endothelial dysfunction is characterized by a shift of the actions of the endothelium toward
reduced vasodilation, a proinflammatory state, and prothrombic properties. It is associated …

Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways …

ATP-sensitive potassium (KATP) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …

Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood
flow that plays an important role in blood pressure (BP) elevation in some models of …

Endothelin-1 (ET-1) is overexpressed in the vascular wall in certain models of experimental
hypertension: deoxycorticosterone acetate salt–treated rats, deoxycorticosterone acetate …

Angiotensin (Ang) II-induced organ damage has fascinated students of hypertension since
the work of Wilson and Byrom. We are investigating a double transgenic rat (dTGR) model …

Background: This study compares plasma endothelin-1 (ET-1) levels in patients with
diabetes mellitus or hypertension with healthy controls, and investigates whether ET-1 levels …

Background: The antihypertensive efficacy and safety of darusentan, a new selective
endothelinA antagonist was investigated. Methods: In a multicenter randomized, double …

L'endothéline-1 (ET-1) est une hormone pléiotrope produite principalement par
l'endothélium. La synthèse de l'ET-1 est stimulée par les principaux signaux de stress …

Cell communication, an essential component of integrated physiological function in
multicellular organisms, is mediated largely through informational molecules, such as …