Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
[HTML][HTML] Primary role of the nucleosome
RD Kornberg, Y Lorch - Molecular cell, 2020 - cell.com
Whereas the core nucleosome is thought to serve as a packaging device for the coiling and
contraction in length of genomic DNA, we suggest that it serves primarily in the regulation of …
contraction in length of genomic DNA, we suggest that it serves primarily in the regulation of …
[HTML][HTML] Genomic nucleosome organization reconstituted with pure proteins
N Krietenstein, M Wal, S Watanabe, B Park… - Cell, 2016 - cell.com
Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but
their individual contributions are obfuscated by the complex in vivo milieu of factor …
their individual contributions are obfuscated by the complex in vivo milieu of factor …
The role of FACT in managing chromatin: disruption, assembly, or repair?
Abstract FACT (FAcilitates Chromatin Transcription) has long been considered to be a
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …
[HTML][HTML] Nucleosome stability distinguishes two different promoter types at all protein-coding genes in yeast
Previous studies indicate that eukaryotic promoters display a stereotypical chromatin
landscape characterized by a well-positioned+ 1 nucleosome near the transcription start site …
landscape characterized by a well-positioned+ 1 nucleosome near the transcription start site …
Transcription-coupled nucleosome assembly
F Robert, C Jeronimo - Trends in Biochemical Sciences, 2023 - cell.com
Eukaryotic transcription occurs on chromatin, where RNA polymerase II encounters
nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the …
nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the …
Opposing chromatin remodelers control transcription initiation frequency and start site selection
Precise nucleosome organization at eukaryotic promoters is thought to be generated by
multiple chromatin remodeler (CR) enzymes and to affect transcription initiation. Using an …
multiple chromatin remodeler (CR) enzymes and to affect transcription initiation. Using an …
[HTML][HTML] Sequence-directed action of RSC remodeler and general regulatory factors modulates+ 1 nucleosome position to facilitate transcription
S Kubik, E O'Duibhir, WJ de Jonge, S Mattarocci… - Molecular cell, 2018 - cell.com
Accessible chromatin is important for RNA polymerase II recruitment and transcription
initiation at eukaryotic promoters. We investigated the mechanistic links between promoter …
initiation at eukaryotic promoters. We investigated the mechanistic links between promoter …
[HTML][HTML] ChEC-seq kinetics discriminates transcription factor binding sites by DNA sequence and shape in vivo
Chromatin endogenous cleavage (ChEC) uses fusion of a protein of interest to micrococcal
nuclease (MNase) to target calcium-dependent cleavage to specific genomic loci in vivo …
nuclease (MNase) to target calcium-dependent cleavage to specific genomic loci in vivo …
[HTML][HTML] Histone recycling by FACT and Spt6 during transcription prevents the scrambling of histone modifications
C Jeronimo, C Poitras, F Robert - Cell reports, 2019 - cell.com
Genomic DNA is framed by additional layers of information, referred to as the epigenome.
Epigenomic marks such as DNA methylation, histone modifications, and histone variants are …
Epigenomic marks such as DNA methylation, histone modifications, and histone variants are …