Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training

B Egan, AP Sharples - Physiological Reviews, 2023 - journals.physiology.org
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

[HTML][HTML] Molecular mechanisms of exercise contributing to tissue regeneration

J Chen, R Zhou, Y Feng, L Cheng - Signal Transduction and Targeted …, 2022 - nature.com
Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …

MicroRNAs as modulators of longevity and the aging process

HE Kinser, Z Pincus - Human genetics, 2020 - Springer
MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally repress
translation or induce mRNA degradation of target transcripts through sequence-specific …

[HTML][HTML] Bone and muscle crosstalk in aging

C He, W He, J Hou, K Chen, M Huang… - Frontiers in Cell and …, 2020 - frontiersin.org
Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the
elderly. Initially, they were thought to be two independent diseases; however, recently …

[HTML][HTML] Roles of mTOR signaling in tissue regeneration

X Wei, L Luo, J Chen - Cells, 2019 - mdpi.com
The mammalian target of rapamycin (mTOR), is a serine/threonine protein kinase and
belongs to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family. mTOR …

Epigenetic changes in healthy human skeletal muscle following exercise–a systematic review

M Jacques, D Hiam, J Craig, R Barrès, N Eynon… - Epigenetics, 2019 - Taylor & Francis
Exercise training is continually challenging whole-body homeostasis, leading to
improvements in performance and health. Adaptations to exercise training are complex and …

Circulating myomiRs: a new class of biomarkers to monitor skeletal muscle in physiology and medicine

J Siracusa, N Koulmann… - Journal of cachexia …, 2018 - Wiley Online Library
MicroRNAs (miRNA) are small non‐coding RNAs that target mRNAs and are consequently
involved in the post‐transcriptional regulation of gene expression. Some miRNAs are …

Potential role of microRNA in the anabolic capacity of skeletal muscle with aging

LM Margolis, DA Rivas - Exercise and sport sciences reviews, 2018 - journals.lww.com
It is well established that mechanical load placed on skeletal muscle during resistance
exercise activates anabolic intracellular signaling processes, increases the rate of muscle …

Circulating microRNA are predictive of aging and acute adaptive response to resistance exercise in men

LM Margolis, SJ Lessard, Y Ezzyat… - … of gerontology series …, 2017 - academic.oup.com
Circulating microRNA (c-miRNA) have the potential to function as novel noninvasive
markers of the underlying physiological state of skeletal muscle. This investigation sought to …