After asthma: redefining airways diseases

ID Pavord, R Beasley, A Agusti, GP Anderson, E Bel… - The Lancet, 2018 - thelancet.com
Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Respiratory syncytial virus

A Jha, H Jarvis, C Fraser… - SARS, MERS and other …, 2016 - library.oapen.org
Respiratory syncytial virus (RSV) infection has an estimated global incidence of 33 million
cases in children younger than 5 years, with 10% requiring hospital admission and up to …

[HTML][HTML] Past, present and future approaches to the prevention and treatment of respiratory syncytial virus infection in children

EAF Simões, L Bont, P Manzoni, B Fauroux… - Infectious diseases and …, 2018 - Springer
Abstract Introduction The REGAL (RSV Evidence–A Geographical Archive of the Literature)
series has provided a comprehensive review of the published evidence in the field of …

A respiratory syncytial virus (RSV) F protein nanoparticle vaccine focuses antibody responses to a conserved neutralization domain

KA Swanson, JN Rainho-Tomko, ZP Williams… - Science …, 2020 - science.org
A stabilized form of the respiratory syncytial virus (RSV) fusion (F) protein has been explored
as a vaccine to prevent viral infection because it presents several potent neutralizing …

[HTML][HTML] Multiepitope-based subunit vaccine design and evaluation against respiratory syncytial virus using reverse vaccinology approach

M Tahir ul Qamar, Z Shokat, I Muneer, UA Ashfaq… - Vaccines, 2020 - mdpi.com
Respiratory syncytial virus (RSV) is primarily associated with respiratory disorders globally.
Despite the availability of information, there is still no competitive vaccine available for RSV …

Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe

Y Alimi, WS Lim, L Lansbury, J Leonardi-Bee… - Journal of Clinical …, 2017 - Elsevier
Community-acquired pneumonia (CAP) is an important respiratory disease and the fifth
leading cause of mortality in Europe. The development of molecular diagnostic tests has …

The immunogenicity and safety of respiratory syncytial virus vaccines in development: A systematic review

J Shan, PN Britton, CL King… - Influenza and other …, 2021 - Wiley Online Library
Background Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory
infection globally. There are vaccine candidates in development, but a systematic review on …

Cell-penetrating peptides: efficient vectors for vaccine delivery

J Yang, Y Luo, MA Shibu, I Toth… - Current drug …, 2019 - ingentaconnect.com
Subunit vaccines are composed of pathogen fragments that, on their own, are generally
poorly immunogenic. Therefore, the incorporation of an immunostimulating agent, eg …

[HTML][HTML] Current state and challenges in developing respiratory syncytial virus vaccines

C Biagi, A Dondi, S Scarpini, A Rocca, S Vandini… - Vaccines, 2020 - mdpi.com
Respiratory syncytial virus (RSV) is the main cause of acute respiratory tract infections in
infants and it also induces significant disease in the elderly. The clinical course may be …

Reduction-responsive codelivery system based on a metal–organic framework for eliciting potent cellular immune response

Y Yang, Q Chen, JP Wu, TB Kirk, J Xu… - ACS applied materials …, 2018 - ACS Publications
Utilizing nanoparticles to deliver subunit vaccines can be viewed as a promising strategy for
enhancing the immune response, especially with regard to cellular immunity to fight against …