Multiomics to elucidate inflammatory bowel disease risk factors and pathways
M Agrawal, KH Allin, F Petralia, JF Colombel… - Nature reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD) is an immune-mediated disease of the intestinal tract, with
complex pathophysiology involving genetic, environmental, microbiome, immunological and …
complex pathophysiology involving genetic, environmental, microbiome, immunological and …
[HTML][HTML] Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease
K Hodgkinson, F El Abbar, P Dobranowski… - Clinical Nutrition, 2023 - Elsevier
Butyrate is a key energy source for colonocytes and is produced by the gut microbiota
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …
Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity
Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current
treatments exclusively target host inflammatory pathways. To understand how host …
treatments exclusively target host inflammatory pathways. To understand how host …
Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer
C Kong, L Liang, G Liu, L Du, Y Yang, J Liu, D Shi, X Li… - Gut, 2023 - gut.bmj.com
Objective The incidence of early-onset colorectal cancer (EO-CRC) is steadily increasing.
Here, we aimed to characterise the interactions between gut microbiome, metabolites and …
Here, we aimed to characterise the interactions between gut microbiome, metabolites and …
Mediterranean-like dietary pattern associations with gut microbiome composition and subclinical gastrointestinal inflammation
Background & Aims Case-control studies have shown that patients with Crohn's disease
(CD) have a microbial composition different from healthy individuals. Although the causes of …
(CD) have a microbial composition different from healthy individuals. Although the causes of …
Implications of the changing epidemiology of inflammatory bowel disease in a changing world
The epidemiology of inflammatory bowel disease (IBD) has undergone considerable shifts
since its emergence in the Western world over a century ago, especially in the last few …
since its emergence in the Western world over a century ago, especially in the last few …
[HTML][HTML] Disease monitoring in inflammatory bowel disease: evolving principles and possibilities
N Plevris, CW Lees - Gastroenterology, 2022 - Elsevier
Inflammatory bowel disease is a progressive and debilitating condition. Early and effective
treatment utilizing a treat to target approach is key in improving patient outcomes. Therefore …
treatment utilizing a treat to target approach is key in improving patient outcomes. Therefore …
Recipient factors in faecal microbiota transplantation: one stool does not fit all
Faecal microbiota transplantation (FMT) is a promising therapy for chronic diseases
associated with gut microbiota alterations. FMT cures 90% of recurrent Clostridioides difficile …
associated with gut microbiota alterations. FMT cures 90% of recurrent Clostridioides difficile …
Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn's disease
Background & Aims The gut microbiome has been suggested to play a role in gut barrier
hemostasis, but data are scarce and limited to animal studies. We therefore aimed to assess …
hemostasis, but data are scarce and limited to animal studies. We therefore aimed to assess …
Location-specific signatures of Crohn's disease at a multi-omics scale
Background Crohn's disease (CD), an inflammatory bowel disease (IBD) subtype, results
from pathologic interactions between host cells and its resident gut microbes. CD manifests …
from pathologic interactions between host cells and its resident gut microbes. CD manifests …