T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Inorganic phosphate (Pi) is essential for signal transduction and cell metabolism, and is also
an essential structural component of the extracellular matrix of the skeleton. Pi is sensed in …

Spinal cord injury (SCI) represents a central nervous system disaster, resulting in the
destruction of spinal cord structure and function and the formation of an adverse …

Basic fibroblast growth factor (FGF)-2 has been shown to regulate many cellular functions
including cell proliferation, migration, and differentiation, as well as angiogenesis in a variety …

As a member of the A Disintegrin And Metalloproteinase (ADAM) family, ADAM10 has been
identified as the constitutive α-secretase in the process of amyloid-β protein precursor …

Prostate cancer (PCa) is by far the most commonly diagnosed cancer in men worldwide.
Despite sensitivity to androgen deprivation, patients with advanced disease eventually …

Metastasis is the predominant reason for high mortality of hepatocellular carcinoma (HCC)
patients. It is critical to explore the molecular mechanism underlying HCC metastasis. Here …

Inherited retinal dystrophies and optic neuropathies cause chronic disabling loss of visual
function. The development of recombinant adeno-associated viral vectors (rAAV) gene …

Considerable progress has been made in our understanding of the process of angiogenesis
in the context of normal and tumor tissue over the last fifty years. Angiogenesis, like most …

Tumors induce angiogenesis to acquire oxygen and nutrition from their adjacent
microenvironment. Tumor angiogenesis has been believed to be induced primarily by the …