Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Aging is the greatest risk factor for late-onset Alzheimer's disease (LOAD), which accounts
for> 95% of Alzheimer's disease (AD) cases. The mechanism underlying the aging-related …

Abstract Calcium (Ca 2+) and reactive oxygen species (ROS) are versatile signaling
molecules coordinating physiological and pathophysiological processes. While channels …

The idea that senescent cells are causally involved in aging has gained strong support from
findings that the removal of such cells alleviates many age‐related diseases and extends …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …

Cellular senescence is a highly complex and programmed cellular state with diverse and, at
times, conflicting physiological and pathological roles across the lifespan of an organism …

It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

Aging leads to a progressive functional decline of the immune system, rendering the elderly
increasingly susceptible to disease and infection. The degree to which immune cell …