The role of ROS-induced pyroptosis in CVD

K Tian, Y Yang, K Zhou, N Deng, Z Tian… - Frontiers in …, 2023 - frontiersin.org
Cardiovascular disease (CVD) is the number one cause of death in the world and seriously
threatens human health. Pyroptosis is a new type of cell death discovered in recent years …

Di (2-ethylhexyl) phthalate and polystyrene microplastics co-exposure caused oxidative stress to activate NF-κB/NLRP3 pathway aggravated pyroptosis and …

S Li, X Gu, M Zhang, Q Jiang, T Xu - Science of The Total Environment, 2024 - Elsevier
Polystyrene microplastic (PS-MPs) contamination has become a worldwide hotspot of
concern, and its entry into organisms can cause oxidative stress resulting in multi-organ …

[HTML][HTML] Melatonin: a window into the organ-protective effects of sepsis

R Liu, X Luo, J Li, Y Lei, F Zeng, X Huang, Y Lan… - Biomedicine & …, 2022 - Elsevier
Sepsis is an uncontrolled host response to infection. In some cases, it progresses to multi-
organ insufficiency, leading to septic shock and increased risk of mortality. Various organ …

A smart cauliflower-like carrier for astaxanthin delivery to relieve colon inflammation

X Zhang, X Zhao, S Tie, J Li, W Su, M Tan - Journal of Controlled Release, 2022 - Elsevier
As a fat-soluble carotenoid, astaxanthin has excellent antioxidant and anti-inflammation
biological activities, but its poor biocompatibility and low stability limit application of …

Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model

D Ye, Y Xu, Y Shi, M Fan, P Lu, X Bai… - Journal of Pineal …, 2022 - Wiley Online Library
Acute ocular hypertension (AOH) is the most important characteristic of acute glaucoma,
which can lead to retinal ganglion cell (RGC) death and permanent vision loss. So far …

Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice

A Wei, D Li, Y Lu, L Yang, Y Zhuo, W Tian… - European journal of …, 2021 - Elsevier
The mortality of sepsis-induced cardiac dysfunction (SICD) is very high due to the complex
pathophysiological mechanism. Syringaresinol (SYR) is a natural abstract which possesses …

Normothermic ex vivo Heart Perfusion Combined With Melatonin Enhances Myocardial Protection in Rat Donation After Circulatory Death Hearts via Inhibiting …

J Lu, L Xu, Z Zeng, C Xue, J Li, X Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Objective The adoption of hearts from donation after circulatory death (DCD) is a promising
approach for the shortage of suitable organs in heart transplantation. However, DCD hearts …

The ameliorative effect of melatonin on LPS-induced Sertoli cells inflammatory and tight junctions damage via suppression of the TLR4/MyD88/NF-κB signaling …

R Feng, SO Adeniran, F Huang, Y Li, M Ma, P Zheng… - Theriogenology, 2022 - Elsevier
The blood-testicular barrier (BTB) is involved in spermatogenesis, protects sperm
development, and plays a crucial role in the reproductive process. Tight junctions (TJs) …

[HTML][HTML] Role of toll-like receptor-mediated pyroptosis in sepsis-induced cardiomyopathy

Y Fan, B Guan, J Xu, H Zhang, L Yi, Z Yang - Biomedicine & …, 2023 - Elsevier
Sepsis, a life-threatening dysregulated status of the host response to infection, can cause
multiorgan dysfunction and mortality. Sepsis places a heavy burden on the cardiovascular …

[HTML][HTML] NLRP3 inflammasome involves in the pathophysiology of sepsis-induced myocardial dysfunction by multiple mechanisms

H Zhang, J Liao, L Jin, Y Lin - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Sepsis-induced myocardial dysfunction (SIMD) is one of the serious health-affecting
problems worldwide. At present, the mechanisms of SIMD are still not clearly elucidated. The …