Design of efficient computational workflows for in silico drug repurposing
Highlights•Conceptual foundations of the drug repurposing paradigm are
reviewed.•Description of the technological trends behind the raise of in silico …
reviewed.•Description of the technological trends behind the raise of in silico …
Computational drug repurposing: current trends
Biomedical discovery has been reshaped upon the exploding digitization of data which can
be retrieved from a number of sources, ranging from clinical pharmacology to …
be retrieved from a number of sources, ranging from clinical pharmacology to …
DDR: efficient computational method to predict drug–target interactions using graph mining and machine learning approaches
Motivation Finding computationally drug–target interactions (DTIs) is a convenient strategy
to identify new DTIs at low cost with reasonable accuracy. However, the current DTI …
to identify new DTIs at low cost with reasonable accuracy. However, the current DTI …
A novel computational approach for drug repurposing using systems biology
Motivation Identification of novel therapeutic effects for existing US Food and Drug
Administration (FDA)-approved drugs, drug repurposing, is an approach aimed to …
Administration (FDA)-approved drugs, drug repurposing, is an approach aimed to …
Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning
Increase in global population and growing disease burden due to the emergence of
infectious diseases (Zika virus), multidrug-resistant pathogens, drug-resistant cancers …
infectious diseases (Zika virus), multidrug-resistant pathogens, drug-resistant cancers …
[HTML][HTML] Polypharmacology guided drug repositioning approach for SARS-CoV2
Drug repurposing has emerged as an important strategy and it has a great potential in
identifying therapeutic applications for COVID-19. An extensive virtual screening of 4193 …
identifying therapeutic applications for COVID-19. An extensive virtual screening of 4193 …
Drug repositioning through network pharmacology
H Ye, J Wei, K Tang, R Feuers… - Current topics in …, 2016 - ingentaconnect.com
Low drug productivity has been a significant problem of the pharmaceutical industry for
several decades even though numerous novel technologies were introduced during this …
several decades even though numerous novel technologies were introduced during this …
Repurposing drugs for glioblastoma: from bench to bedside
Glioblastoma multiforme is the most common, aggressive and lethal type of brain tumor. It is
a stage IV cancer disease with a poor prognosis, as the current therapeutic options (surgery …
a stage IV cancer disease with a poor prognosis, as the current therapeutic options (surgery …
DrugR+: a comprehensive relational database for drug repurposing, combination therapy, and replacement therapy
Drug repurposing or repositioning, which introduces new applications of the existing drugs,
is an emerging field in drug discovery scope. To enhance the success rate of the research …
is an emerging field in drug discovery scope. To enhance the success rate of the research …
How good are publicly available web services that predict bioactivity profiles for drug repurposing?
KA Murtazalieva, DS Druzhilovskiy… - SAR and QSAR in …, 2017 - Taylor & Francis
Drug repurposing provides a non-laborious and less expensive way for finding new human
medicines. Computational assessment of bioactivity profiles shed light on the hidden …
medicines. Computational assessment of bioactivity profiles shed light on the hidden …