Administration of both streptozotocin (STZ) and nicotinamide (NA) has been proposed to
induce experimental diabetes in the rat. STZ is well known to cause pancreatic B-cell …

Overweight and obesity are global health problems that affect more than 1.9 billion adults
who are overweight, and of these 600 million are obese. In the United States, these …

Cigarette smoking during pregnancy is associated with numerous obstetrical, fetal, and
developmental complications, as well as an increased risk of adverse health consequences …

OBJECTIVE—β-Cells are particularly susceptible to fatty acid–induced apoptosis associated
with decreased insulin receptor/phosphatidylinositol-3 kinase/Akt signaling and the …

Human islet isolation leads to the loss of the ECM basement membrane which contributes to
eventual apoptosis in vitro. The reestablishment of this environment is vital in understanding …

Diabetes is one of the most prevalent, costly, and debilitating diseases in the world.
Although traditional insulin therapy has alleviated the short-term effects, long-term …

Pancreatic islet transplantation is a promising method for treatment of type 1 diabetes
mellitus. However, transplanted islets can be destroyed due to host immune reactions. To …

Type 2 diabetes is the most common form of diabetes in humans. It results from a
combination of factors that impair beta-cell function and tissue insulin sensitivity. However …

Growth differentiation factor 11 (GDF11) has been implicated in the regulation of islet
development and a variety of aging conditions, but little is known about the physiological …

The objective of this study was to determine whether the combination therapy of
intrapancreatic autologous stem cell infusion (ASC) and hyperbaric oxygen treatment (HBO) …