MHC class II (MHC-II) molecules are critical in the control of many immune responses. They
are also involved in most autoimmune diseases and other pathologies. Here, we describe …

In antigen‐presenting cells (APCs), loading of major histocompatibility complex class II
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …

Graves' disease (GD) is associated with HLA-DR3 (DRB1* 03) in Caucasians, but the exact
amino-acid sequence in the DR β1 chain conferring susceptibility to GD is unknown …

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …

The human leukocyte antigen class II genes DRB1, DQB1, and DQA1 are associated with
Graves disease (GD), but, because of strong linkage disequilibrium within this region, the …

HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …

Atypical invariant chain (Ii) CLIP fragments (CLIP2) have been found in association with HLA-
DQ2 (DQ2) purified from cell lysates. We mapped the binding register of CLIP2 (Ii 96–104) to …

Major histocompatibility complex (MHC) class II molecules are membrane-anchored
heterodimers that present antigenic peptides to T cells. Expression of these molecules in …

Classical HLA class II molecules are highly polymorphic heterodimeric transmembrane
proteins encoded by a polygenic cluster on chromosome 6. Polymorphic residues in the …

Background The classical human leucocyte antigen (HLA) genes were the most important
genetic determinant for Graves' disease (GD). The aim of the study was to fine map causal …