Variations in MHC class II antigen processing and presentation in health and disease
ER Unanue, V Turk, J Neefjes - Annual review of immunology, 2016 - annualreviews.org
MHC class II (MHC-II) molecules are critical in the control of many immune responses. They
are also involved in most autoimmune diseases and other pathologies. Here, we describe …
are also involved in most autoimmune diseases and other pathologies. Here, we describe …
Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression
R Busch, CH Rinderknecht, S Roh… - Immunological …, 2005 - Wiley Online Library
In antigen‐presenting cells (APCs), loading of major histocompatibility complex class II
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …
Arginine at position 74 of the HLA-DR β1 chain is associated with Graves' disease
Y Ban, TF Davies, DA Greenberg, ES Concepcion… - Genes & …, 2004 - nature.com
Graves' disease (GD) is associated with HLA-DR3 (DRB1* 03) in Caucasians, but the exact
amino-acid sequence in the DR β1 chain conferring susceptibility to GD is unknown …
amino-acid sequence in the DR β1 chain conferring susceptibility to GD is unknown …
[HTML][HTML] MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange
ET Abualrous, S Stolzenberg, J Sticht… - Nature Chemical …, 2023 - nature.com
Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …
[HTML][HTML] Regression mapping of association between the human leukocyte antigen region and Graves disease
MJ Simmonds, JMM Howson, JM Heward… - The American Journal of …, 2005 - cell.com
The human leukocyte antigen class II genes DRB1, DQB1, and DQA1 are associated with
Graves disease (GD), but, because of strong linkage disequilibrium within this region, the …
Graves disease (GD), but, because of strong linkage disequilibrium within this region, the …
[HTML][HTML] Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide
L Yin, P Trenh, A Guce, M Wieczorek, S Lange… - Journal of Biological …, 2014 - ASBMB
HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …
presentation by a mechanism that remains unclear and controversial. Here, we investigated …
Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM
LE Fallang, S Roh, A Holm, E Bergseng… - The Journal of …, 2008 - journals.aai.org
Atypical invariant chain (Ii) CLIP fragments (CLIP2) have been found in association with HLA-
DQ2 (DQ2) purified from cell lysates. We mapped the binding register of CLIP2 (Ii 96–104) to …
DQ2 (DQ2) purified from cell lysates. We mapped the binding register of CLIP2 (Ii 96–104) to …
Directed evolution of soluble single-chain human class II MHC molecules
O Esteban, H Zhao - Journal of molecular biology, 2004 - Elsevier
Major histocompatibility complex (MHC) class II molecules are membrane-anchored
heterodimers that present antigenic peptides to T cells. Expression of these molecules in …
heterodimers that present antigenic peptides to T cells. Expression of these molecules in …
On the structure–function of MHC class II molecules and how single amino acid polymorphisms could alter intracellular trafficking
J Thibodeau, MA Moulefera, R Balthazard - Human Immunology, 2019 - Elsevier
Classical HLA class II molecules are highly polymorphic heterodimeric transmembrane
proteins encoded by a polygenic cluster on chromosome 6. Polymorphic residues in the …
proteins encoded by a polygenic cluster on chromosome 6. Polymorphic residues in the …
Fine mapping MHC associations in Graves' disease and its clinical subtypes in Han Chinese
X Chu, M Yang, ZJ Song, Y Dong, C Li… - Journal of medical …, 2018 - jmg.bmj.com
Background The classical human leucocyte antigen (HLA) genes were the most important
genetic determinant for Graves' disease (GD). The aim of the study was to fine map causal …
genetic determinant for Graves' disease (GD). The aim of the study was to fine map causal …