Delirium pathophysiology: an updated hypothesis of the etiology of acute brain failure

JR Maldonado - International journal of geriatric psychiatry, 2018 - Wiley Online Library
Background Delirium is the most common neuropsychiatric syndrome encountered by
clinicians dealing with older adults and the medically ill and is best characterized by 5 core …

Neuropathogenesis of delirium: review of current etiologic theories and common pathways

JR Maldonado - The American Journal of Geriatric Psychiatry, 2013 - Elsevier
Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity
secondary to systemic disturbances. Over time, a number of theories have been proposed in …

[HTML][HTML] A multicomponent intervention to prevent delirium in hospitalized older patients

SK Inouye, ST Bogardus Jr… - New England journal …, 1999 - Mass Medical Soc
Background Since in hospitalized older patients delirium is associated with poor outcomes,
we evaluated the effectiveness of a multicomponent strategy for the prevention of delirium …

Intraoperative electroencephalogram suppression predicts postoperative delirium

BA Fritz, PL Kalarickal, HR Maybrier… - Anesthesia & …, 2016 - journals.lww.com
BACKGROUND: Postoperative delirium is a common complication associated with
increased morbidity and mortality, longer hospital stays, and greater health care …

[HTML][HTML] Risk factors for delirium in intensive care patients: a prospective cohort study

B Van Rompaey, MM Elseviers, MJ Schuurmans… - Critical care, 2009 - Springer
Introduction Delirium is a common complication in the intensive care unit. The attention of
researchers has shifted from the treatment to the prevention of the syndrome necessitating …

Interventions for preventing intensive care unit delirium in adults

SF Herling, IE Greve, EE Vasilevskis… - Cochrane Database …, 2018 - cochranelibrary.com
Background Delirium is defined as a disturbance in attention, awareness and cognition with
reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the …

Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery

JR Maldonado, A Wysong, PJA Van Der Starre, T Block… - Psychosomatics, 2009 - Elsevier
Background Delirium is a neurobehavioral syndrome caused by the transient disruption of
normal neuronal activity secondary to systemic disturbances. Objective The authors …

[HTML][HTML] The effect of earplugs during the night on the onset of delirium and sleep perception: a randomized controlled trial in intensive care patients

B Van Rompaey, MM Elseviers, W Van Drom… - Critical care, 2012 - Springer
Introduction This study hypothesised that a reduction of sound during the night using
earplugs could be beneficial in the prevention of intensive care delirium. Two research …

Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine …

Y Shehabi, P Grant, H Wolfenden… - The Journal of the …, 2009 - pubs.asahq.org
Background Commonly used sedatives/analgesics can increase the risk of postoperative
complications, including delirium. This double-blinded study assessed the neurobehavioral …

Pathoetiological model of delirium: a comprehensive understanding of the neurobiology of delirium and an evidence-based approach to prevention and treatment

JR Maldonado - Critical care clinics, 2008 - Elsevier
Delirium is the most common complication found in the general hospital setting. Yet, we
know relatively little about its actual pathophysiology. This article contains a summary of …