This review is an updated and expanded version of the five prior reviews that were
published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic …

Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …

Natural products are the result of Nature's exploration of biologically relevant chemical
space through evolution and an invaluable source of bioactive small molecules for chemical …

Chlorine is one of the most common atoms present in small-molecule drugs beyond carbon,
hydrogen, nitrogen, and oxygen. There are currently more than 250 FDA-approved chlorine …

Sprouts and microgreens have attracted tremendous interest across multiple disciplines in
recent years. Here, we critically review the most recent advances to underscore research …

Predicting protein–ligand binding affinity is a central issue in drug design. Various deep
learning models have been published in recent years, where many of them rely on 3D …

This review seeks to provide a timely survey of the scope and limitations of cheminformatics
methods in natural product‐based drug discovery. Following an overview of data resources …

Covering: up to 2021 The structural core of most small-molecule drugs is formed by a ring
system, often derived from natural products. However, despite the importance of natural …

All pharmaceutical products contain organic molecules; the source may be a natural product
or a fully synthetic molecule, or a combination of both. Thus, it follows that organic chemistry …

Technological advances and practical applications of the chemical space concept in drug
discovery, natural product research, and other research areas have attracted the scientific …