The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …

Gastric cancer is one of the most common malignant tumors in the world. In China, its
morbidity and mortality are second only to lung cancer. Chemotherapy combined with …

Currently, there is no reliable biomarker to clinically predict the prognosis of lung
adenocarcinoma (ADC). The receptor-tyrosine-kinase like orphan receptor 1 (ROR1) is …

Receptor tyrosine kinase ROR1, an embryonic protein involved in organogenesis, is
expressed in certain hematological malignancies and solid tumors, but is generally absent …

Simple Summary Inflammation is the biological response of the body to damaging and toxic
stimuli, and is a positive event that evolves with the resolution of critical events (acute …

Mesenchymal stem cells (MSCs) are recruited and activated by solid tumors and play a role
in tumor progression and metastasis. Here we show that MSCs promote metastasis in a …

In the past decade, a shift toward targeted therapies in non-small-cell lung cancer following
molecular profiling has dramatically changed the way advanced adenocarcinoma is treated …

Efforts were directed on the design, synthesis and evaluation of the anticancer activity of
some pyrimidine-based hydrazones against two breast cancer cell lines, MCF-7 and MDA …

The EGFR and TGFβ signaling pathways are important mediators of tumorigenesis, and
cross-talk between them contributes to cancer progression and drug resistance. Therapies …

Glioblastoma multiforme (GBM) is one of the aggressive brain cancers with patients having
less survival period upto 12–15 months. Mammalian target of rapamycin (mTOR) is a …