Background Evidence on the role of curative metastasectomy (CM) for malignant melanoma
(MM) patients is limited, especially in the current era of effective systemic therapy. A …

Metastatic melanoma is a fatal malignancy with a high mortality and morbidity. Since the
early 1970s, available medical therapies were limited in improving survival. Surgery …

Background Cutaneous melanoma and distant organ metastasis has varying outcomes.
Considering all prognostic indicators in a prediction model might assist in selecting cases …

PMCA4 is a critical regulator of Ca2+ homeostasis in mammalian cells. While its biological
and prognostic relevance in several cancer types has already been demonstrated, only …

Simple Summary Since the introduction of effective systemic therapies (ESTs)(in the form of
both targeted and immuno-based therapies) in the treatment of malignant melanoma, the …

Simple Summary Lung metastases are a major challenge in advanced cancer treatment
because they are common and difficult to manage. This study assesses the effectiveness of …

Methods: A literature review was conducted using the PubMed/MEDLINE database
including all relevant articles through March 2023. Articles were reviewed for relevance by …

Pulmonary metastasectomy in colorectal cancer (CRC) has encouraging results; however,
specific criteria for lung resection and the timing of resection remain undetermined …

The management of malignant melanoma with pulmonary metastases is controversial and
occasionally requires multimodality management, including pulmonary metastasectomy …

DISCUSSION There are many differential diagnoses for pulmonary lung nodules, and
biopsy is frequently required in lesions of high malignant risk. The advancement in …