Normothermic machine perfusion systems: where do we go from here?
S López-Martínez, C Simón, X Santamaria - Transplantation, 2024 - journals.lww.com
Normothermic machine perfusion (NMP) aims to preserve organs ex vivo by simulating
physiological conditions such as body temperature. Recent advancements in NMP system …
physiological conditions such as body temperature. Recent advancements in NMP system …
Simply adding oxygen during hypothermic machine perfusion to combat the negative effects of ischemia-reperfusion injury: fundamentals and current evidence for …
T Darius, J Nath, M Mourad - Biomedicines, 2021 - mdpi.com
The use of high-risk renal grafts for transplantation requires optimization of pretransplant
preservation and assessment strategies to improve clinical outcomes as well as to decrease …
preservation and assessment strategies to improve clinical outcomes as well as to decrease …
Shifting paradigms for suppressing fibrosis in kidney transplants: supplementing perfusion solutions with anti-fibrotic drugs
LL van Leeuwen, HGD Leuvenink, P Olinga… - Frontiers in …, 2022 - frontiersin.org
Great efforts have been made toward addressing the demand for donor kidneys. One of the
most promising approaches is to use kidneys from donation after circulatory death donors …
most promising approaches is to use kidneys from donation after circulatory death donors …
[HTML][HTML] Utilizing pathophysiological concepts of ischemia-reperfusion injury to design renoprotective strategies and therapeutic interventions for normothermic ex vivo …
B Ogurlu, TL Hamelink, IM Van Tricht… - American Journal of …, 2024 - Elsevier
Normothermic machine perfusion (NMP) has emerged as a promising tool for the
preservation, viability assessment, and repair of deceased-donor kidneys prior to …
preservation, viability assessment, and repair of deceased-donor kidneys prior to …
Preservation of organs to be transplanted: An essential step in the transplant process
M Lepoittevin, S Giraud, T Kerforne, B Barrou… - International Journal of …, 2022 - mdpi.com
Organ transplantation remains the treatment of last resort in case of failure of a vital organ
(lung, liver, heart, intestine) or non-vital organ (essentially the kidney and pancreas) for …
(lung, liver, heart, intestine) or non-vital organ (essentially the kidney and pancreas) for …
Loss of endothelial glycocalyx during normothermic machine perfusion of porcine kidneys irrespective of pressure and hematocrit
TM Huijink, CJ van't Hof, LA Van Furth… - Transplantation …, 2023 - journals.lww.com
Background. Normothermic machine perfusion (NMP) is a promising modality for marginal
donor kidneys. However, little is known about the effects of NMP on causing endothelial …
donor kidneys. However, little is known about the effects of NMP on causing endothelial …
Prolonged controlled oxygenated rewarming improves immediate tubular function and energetic recovery of porcine kidneys during normothermic machine perfusion
B Ogurlu, CC Pamplona, IM Van Tricht… - …, 2023 - journals.lww.com
Background. Normothermic machine perfusion (NMP) is typically performed after a period of
hypothermic preservation, which exposes the kidney to an abrupt increase in temperature …
hypothermic preservation, which exposes the kidney to an abrupt increase in temperature …
Preoperative function assessment of ex vivo kidneys with supervised machine learning based on blood and urine markers measured during normothermic machine …
W Markgraf, H Malberg - Biomedicines, 2022 - mdpi.com
Establishing an objective quality assessment of an organ prior to transplantation can help
prevent unnecessary discard of the organ and reduce the probability of functional failure. In …
prevent unnecessary discard of the organ and reduce the probability of functional failure. In …
Exploring porcine precision-cut kidney slices as a model for transplant-related ischemia-reperfusion injury
LA van Furth, HGD Leuvenink, L Seras, IAM de Graaf… - Transplantology, 2022 - mdpi.com
Marginal donor kidneys are more likely to develop ischemia-reperfusion injury (IRI),
resulting in inferior long-term outcomes. Perfusion techniques are used to attenuate IRI and …
resulting in inferior long-term outcomes. Perfusion techniques are used to attenuate IRI and …
[HTML][HTML] 48 h normothermic machine perfusion with urine recirculation for discarded human kidney grafts
F Messner, A Soleiman, D Öfner… - Transplant …, 2023 - frontierspartnerships.org
Background: Normothermic machine perfusion (NMP) has reshaped organ preservation in
recent years. In this preclinical study, prolonged normothermic perfusions of discarded …
recent years. In this preclinical study, prolonged normothermic perfusions of discarded …