Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

Regenerative medicine has been attracting tremendous attention during the past few
decades because it is promising in overcoming the limitations of donor shortage and …

Islets derived from stem cells hold promise as a therapy for insulin-dependent diabetes, but
there remain challenges towards achieving this goal,,,,–. Here we generate human islet-like …

Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …

Cell-identity switches, in which terminally differentiated cells are converted into different cell
types when stressed, represent a widespread regenerative strategy in animals, yet they are …

Background Impaired or hyperactive pancreas regeneration after injury would cause
exocrine insufficiency or recurrent/chronic pancreatitis and potentially carcinogenesis …

Background The pancreas is small and irregular in shape in people with type 2 diabetes. If
these abnormalities are caused by the disease state itself rather than being a predisposing …

Dedifferentiation of insulin-secreting β cells in the islets of Langerhans has been proposed
to be a major mechanism of β-cell dysfunction. Whether dedifferentiated β cells can be …

Gut stem cells are accessible by biopsy and propagate robustly in culture, offering an
invaluable resource for autologous cell therapies. Insulin-producing cells can be induced in …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …