FAK in cancer: mechanistic findings and clinical applications

FJ Sulzmaier, C Jean, DD Schlaepfer - Nature reviews cancer, 2014 - nature.com
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Angiogenesis and vasculogenesis in rheumatoid arthritis

Z Szekanecz, T Besenyei, Á Szentpétery… - Current opinion in …, 2010 - journals.lww.com
Angiogenesis and vasculogenesis in rheumatoid arthritis : Current Opinion in
Rheumatology Angiogenesis and vasculogenesis in rheumatoid arthritis : Current Opinion …

Interleukin‐34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment

AI Ségaliny, A Mohamadi, B Dizier… - … journal of cancer, 2015 - Wiley Online Library
Interleukin‐34 (IL‐34) was recently characterized as the M‐CSF “twin” cytokine, regulating
the proliferation/differentiation/survival of myeloid cells. The implication of M‐CSF in …

Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis

E Lee, EJ Fertig, K Jin, S Sukumar, NB Pandey… - Nature …, 2014 - nature.com
Breast cancer metastasis involves lymphatic dissemination in addition to hematogenous
spreading. Although stromal lymphatic vessels (LVs) serve as initial metastatic routes, roles …

Upregulated cytoskeletal proteins promote pathological angiogenesis in moyamoya disease

S He, J Zhang, Z Liu, Y Wang, X Hao, X Wang, Z Zhou… - Stroke, 2023 - Am Heart Assoc
BACKGROUND: Moyamoya disease (MMD) is a rare progressive vascular disease that
leads to intracranial internal carotid artery stenosis and eventual occlusion. However, its …

Targeting of proangiogenic signalling pathways in chronic inflammation

SW Tas, CX Maracle, E Balogh… - Nature Reviews …, 2016 - nature.com
Angiogenesis is de novo capillary outgrowth from pre-existing blood vessels. This process
not only is crucial for normal development, but also has an important role in supplying …

The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer

S Tiede, N Meyer-Schaller, RKR Kalathur, R Ivanek… - Oncogenesis, 2018 - nature.com
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that regulates a plethora of
downstream signaling pathways essential for cell migration, proliferation and death …

Ruthenium polypyridyl complex inhibits growth and metastasis of breast cancer cells by suppressing FAK signaling with enhancement of TRAIL-induced apoptosis

W Cao, W Zheng, T Chen - Scientific reports, 2015 - nature.com
Ruthenium-based complexes have emerged as promising antitumor and antimetastatic
agents during the past decades. However, the limited understanding of the antimetastatic …

Control of vascular permeability by adhesion molecules

IH Sarelius, AJ Glading - Tissue barriers, 2015 - Taylor & Francis
Vascular permeability is a vital function of the circulatory system that is regulated in large
part by the limited flux of solutes, water, and cells through the endothelial cell layer. One …

Behind Brain Metastases Formation: Cellular and Molecular Alterations and Blood–Brain Barrier Disruption

J Godinho-Pereira, AR Garcia, I Figueira… - International journal of …, 2021 - mdpi.com
Breast cancer (BC) brain metastases is a life-threatening condition to which accounts the
poor understanding of BC cells'(BCCs) extravasation into the brain, precluding the …