Annexins constitute an evolutionary conserved multigene protein superfamily characterized
by their ability to interact with biological membranes in a calcium dependent manner. They …

Annexins are small proteins capable of membrane attachment or insertion. Animal annexins
can form Ca 2+-permeable conductances in planar lipid bilayers or vesicles. Some have …

Highlights•HS-AFM detects conformational changes of unlabeled membrane proteins.•In situ
responses to pH, ligands, temperature and light can be visualized.•Developments in …

Integral membrane proteins are embedded in a watersolvated lipid bilayer that presents
contrasting features in an anisotropic, chemically heterogeneous environment. A …

Identifying a universal biomarker for cancer treatment remains a major challenge in cancer
therapy. Extracellular exposure of phosphatidylserine (PS) is tightly regulated and is an “eat …

Dynamics are fundamental to the functions of biomolecules and can occur on a wide range
of time and length scales. Here we develop and apply high-speed AFM height spectroscopy …

At the cell surface, activation of the epidermal growth factor (EGF) receptor triggers a
complex network of signalling events that regulate a variety of cellular processes. For signal …

Annexins are abundant cytoplasmic proteins that can bind to negatively charged
phospholipids in a Ca2+-dependent manner, and are known to play a role in the storage of …

Caveolins form plasmalemnal invaginated caveolae. They also locate around intracellular
lipid droplets but their role in this location remains unclear. By studying primary adipocytes …

Chemically modified antisense oligonucleotides (ASOs) designed to mediate site-specific
cleavage of RNA by RNase H1 are used as research tools and as therapeutics. ASOs …