Immunochemical staining to detect ubiquitin has become an essential technique in
evaluating neurodegenerative processes. Age related staining is seen in myelin, in nerve …

Using the techniques of molecular biology, recent experimental studies have shown that
cerebral ischemia induces a variety of changes in gene expression in the brain. During the …

The last several years have been a landmark period in the ubiquitin field. The breadth of
ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent …

Post-translational protein modifications present an elegant and energy efficient way to
dynamically reprogram cellular protein properties and functions in response to homeostatic …

Ubiquitin, which can conjugate with cellular proteins, is classified into two forms: free
ubiquitin and multiubiquitin chains. The latter is active as a signal for degradation of the …

The time-dependent expression of ubiquitin (Ub) was examined in murine skin wounds and
55 human skin wounds with different wound ages (groups I: 0–12 h, II: 1–5 days, III: 7–14 …

The mechanisms underlying neurologic deficits and delayed neuronal death after ischemia
are not fully understood. In the present study, we report that transient cerebral ischemia …

Ubiquitylation is a posttranslational protein modification that modulates various cellular
processes of key significance, including protein degradation and DNA damage repair. In …

Despite the distinction between ischemic stroke and neurodegenerative disorders, they
share numerous pathophysiologies particularly those mediated by inflammation and …

We investigated ubiquitin immunoreactivity in the post-ischemic gerbil hippocampus using a
panel of ubiquitin antibodies. Immunostaining for ubiquitin in the hippocampus was strongly …