[HTML][HTML] Beyond erectile dysfunction: cGMP-specific phosphodiesterase 5 inhibitors for other clinical disorders
Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger,
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …
The sexual long COVID (SLC): erectile dysfunction as a biomarker of systemic complications for COVID-19 long haulers
A Sansone, D Mollaioli, E Limoncin… - Sexual Medicine …, 2022 - academic.oup.com
Introduction Long term complications of COVID-19, the disease caused by the SARS-CoV-2,
involve many organ systems, dramatically worsening the quality of life, and finally …
involve many organ systems, dramatically worsening the quality of life, and finally …
A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways
Aims The present study aimed to investigate the effect of nano selenium, sildenafil, and their
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …
[HTML][HTML] The British Society for Sexual Medicine guidelines on male adult testosterone deficiency, with statements for practice
Testosterone deficiency (TD) is an increasingly common problem with significant health
implications, but its diagnosis and management can be challenging. A multi-disciplinary …
implications, but its diagnosis and management can be challenging. A multi-disciplinary …
[HTML][HTML] Gut probiotic Lactobacillus rhamnosus attenuates PDE4B-mediated interleukin-6 induced by SARS-CoV-2 membrane glycoprotein
MT Pham, AJ Yang, MS Kao, U Gankhuyag… - The Journal of …, 2021 - Elsevier
Membrane glycoprotein is the most abundant protein of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), but its role in coronavirus disease 2019 (COVID-19) has not …
coronavirus 2 (SARS-CoV-2), but its role in coronavirus disease 2019 (COVID-19) has not …
[HTML][HTML] PDE5 inhibitors: breaking new grounds in the treatment of COVID-19
R Varghese, G Digholkar, J Karsiya, S Salvi… - Drug metabolism and …, 2023 - degruyter.com
Introduction Despite the ever-increasing occurrences of the coronavirus disease (COVID-19)
cases around the world, very few medications have been validated in the clinical trials to …
cases around the world, very few medications have been validated in the clinical trials to …
[HTML][HTML] Sildenafil 4.0—Integrated synthetic chemistry, formulation and analytical strategies effecting immense therapeutic and societal impact in the fourth industrial …
A Ouranidis, A Tsiaxerli, E Vardaka, CK Markopoulou… - Pharmaceuticals, 2021 - mdpi.com
Sildenafil is a potent selective, reversible inhibitor of phosphodiesterase type 5 (PDE5)
approved for the treatment of erectile dysfunction and pulmonary arterial hypertension …
approved for the treatment of erectile dysfunction and pulmonary arterial hypertension …
[HTML][HTML] Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections
Although the antimicrobial potential of nitric oxide (NO) is widely published, it is little used
clinically. NO is a key signalling molecule modulating vascular, neuronal, inflammatory and …
clinically. NO is a key signalling molecule modulating vascular, neuronal, inflammatory and …
Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise
PP Oza, K Kashfi - Nitric Oxide, 2022 - Elsevier
Viral infections are a continuing global burden on the human population, underscored by the
ramifications of the COVID-19 pandemic. Current treatment options and supportive therapies …
ramifications of the COVID-19 pandemic. Current treatment options and supportive therapies …
Pulmonary Arterial Hypertension and COVID-19: piecing the puzzle
F Charif, F Dakroub, IB Akl, M Kularatne… - Respiratory medicine and …, 2023 - Elsevier
COVID-19 remains a health care concern despite the end of the pandemic. Patients with
cardiovascular disease (CVD) are at a higher risk for developing severe COVID-19 …
cardiovascular disease (CVD) are at a higher risk for developing severe COVID-19 …