Infertility is defined as the inability of couples to have a baby after one year of regular
unprotected intercourse, affecting 10 to 15% of couples. According to the latest WHO …

Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …

Activation of caspase, externalization of phosphatidyl serine, change in the mitochondrial
membrane potential, and DNA fragmentation are apoptosis markers found in human …

OBJECTIVE: This study was designed to explore the relationship between men's age and
DNA damage and apoptosis in human spermatozoa. DESIGN: Semen samples were …

Protein ubiquitination is a reversible reaction, in which the ubiquitin chains are
deconjugated by a family of deubiquitinases (DUBs). The presence of a large number of …

Caspases, a family of evolutionarily, conserved cysteinyl proteases, mediate both apoptosis
and inflammation through aspartate-specific cleavage of a wide number of cellular …

OBJECTIVE: To evaluate ejaculated spermatozoa from patients with male factor infertility for
the role of cytochrome c and caspases 9 and 3 (the proteins known to mediate apoptosis) …

Normal testicular function is dependent upon hormones acting through endocrine and
paracrine pathways both in vivo and in vitro. Sertoli cells provide factors necessary for the …

The present study was conducted to detect sperm apoptosis in fresh and frozen semen and
to determine its relationship with bull fertility. Three ejaculates were collected from five …

BACKGROUND: The pathophysiology of the testicular damage in varicocele has not been
completely understood. Oxidative stress and related sperm DNA damage have been …