A series of biphenyl analogues of the new tuberculosis drug PA-824 was prepared, primarily
by coupling the known (6 S)-2-nitro-6, 7-dihydro-5 H-imidazo [2, 1-b][1, 3] oxazin-6-ol with …

Tuberculosis (TB) is an infection caused by Mycobacterium tuberculosis (Mtb) and one of the
deadliest infectious diseases in the world. Mtb has the ability to become dormant within the …

The emergence of multidrug-resistant strains of Mycobacterium tuberculosis and resistance
to current anti-TB drugs call for the discovery and development of new effective anti-TB …

Tuberculosis caused by Mycobacterium tuberculosis is an infectious bacterial disease which
is a leading cause of mortality affecting more than 9 million people worldwide. The current …

The antitubercular activity of ortho-, meta-and para-substituted biphenyl analogs of 2-
nitroimidazo [2, 1-b][1, 3] oxazine has been analyzed through combinatorial protocol in …

Background: The neuroleptic chlorpromazine has been reported for antitubercular activity
but the associated antipsychotic activity restricted its clinical presentation. Objectives: Novel …

Synthetic studies of two classes of natural products, ascididemin and 6-stryl-4-methoxy-2-
pyranone, are described. Compounds produced in these studies were submitted to a …

Background: An efficient one-pot biocatalysed ultrasound assisted synthesis of
dihydropyrimidinones/thiones has been developed under solvent free conditions. Materials …

Tuberculosis (TB) remains a dominant infectious disease causing morbidity and mortality
worldwide. 1, 2 It is estimated that one-third of the world's population is latently infected with …

Unlike most infectious diseases that mainly affect the developing world, lower respiratory
tract infections (LRTI) are just as important to the developed world. They are the leading …