Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy.
Autophagy plays an important role on intracellular metabolic homeostasis by eliminating …

A hallmark feature of tumorigenesis is uncontrolled cell division. Autophagy is regulated by
more than 30 genes and it is one of several mechanisms by which cells maintain …

Background High-mobility group box 1 (HMGB1) is a multifunctional redox-sensitive protein
involved in various intracellular (eg, chromatin remodeling, transcription, autophagy) and …

Background Chemotherapeutics can stimulate immune antitumor response by inducing
immunogenic cell death (ICD), which is activated by Damage-Associated Molecular Patterns …

Abstract Background Long non-coding RNAs (lncRNAs) have been reported to regulate the
sensitivity of different cancer cells to chemoradiotherapy. Aberrant expression of lncRNA …

Background Circular RNAs (circRNAs) have been closely implicated in competing
endogenous RNA (ceRNA) network among human cancers including non‐small cell lung …

Cytotoxic effects of Metvan (cis-[V IV O (OSO 3)(Me 2 phen) 2], where Me 2 phen= 4, 7-
dimethyl-1, 10-phenanthroline) and its analogues with 1, 10-phenanthroline (phen) and 2 …

Objectives: Immune checkpoint (ICP) expression in tumor cells could directly or indirectly
affect the results of immunotherapy. ICP ligands on tumor cells usually bind their immune …

Alterations in lipid metabolism, commonly disregarded in the past, have been accepted as a
hallmark for cancer. Exploring cancer therapeutics that interrupt the lipid metabolic pathways …

Paclitaxel (PTX) is one of standard chemotherapy drug for patients with metastatic castration-
resistant prostate cancer (mCRPC). However, PTX resistance leads to treatment failures, for …