Following the identification of several disease-associated polymorphisms by genome-wide
association (GWA) analysis, interest is now focusing on the detection of effects that, owing to …

Motivation: The sequencing of the human genome has made it possible to identify an
informative set of> 1 million single nucleotide polymorphisms (SNPs) across the genome …

Motivation: Polymorphisms in human genes are being described in remarkable numbers.
Determining which polymorphisms and which environmental factors are associated with …

There is increasing awareness that epistasis or gene-gene interaction plays a role in
susceptibility to common human diseases. In this paper, we formulate a working hypothesis …

Detecting, characterizing, and interpreting gene–gene interactions or epistasis in studies of
human disease susceptibility is both a mathematical and a computational challenge. To …

Epistatic interactions among multiple genetic variants in the human genome may be
important in determining individual susceptibility to common diseases. Although some …

Multifactor dimensionality reduction (MDR) was developed as a method for detecting
statistical patterns of epistasis. The overall goal of MDR is to change the representation …

The identification and characterization of genes that influence the risk of common, complex
multifactorial diseases, primarily through interactions with other genes and other …

The widespread availability of high-throughput genotyping technology has opened the door
to the era of personal genetics, which brings to consumers the promise of using genetic …

Methodological and conceptual advances in human genetics have led to the identification of
an impressive number of human disease genes. This wealth of information has also …