The last 50 years have witnessed extraordinary developments in understanding
mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical …

Small cell lung cancer (SCLC) remains the most fatal form of lung cancer, with patients in
dire need of new and effective therapeutic approaches. Modeling SCLC in an …

The management of osteosarcoma (OS) patients presents a significant clinical challenge.
Despite progress in conventional and targeted therapies, the survival rate of OS patients …

Organoids are three-dimensional (3D) structures that can be derived from stem cells or adult
tissue progenitor cells and exhibit an extraordinary ability to autonomously organize and …

Understanding the mechanisms involved in colonic epithelial differentiation is key to
unraveling the alterations causing inflammatory conditions and cancer. Organoid cultures …

Intestinal metaplasia (IM) is classified into complete intestinal metaplasia (CIM) and
incomplete intestinal metaplasia (IIM). Patients diagnosed with IIM face an elevated …

Recent advancements in modern science have provided robust tools for drug discovery. The
rapid development of transcriptome sequencing technologies has given rise to single-cell …

In this study, a series of 2-Aryl-1H-benzo [d] imidazole derivatives were developed to target
intra-and extracellular microtubule networks. Compounds O-7 and O-10 showed impressive …

目的建立微乳头型肺腺癌类器官的培养方法, 并开展靶向药物的筛选. 方法自确诊为微乳头型肺
腺癌患者手术组织样本中提取和培养原代肺癌类器官, 动态观察和记录肺癌类器官生长情况; …

Functional precision oncology represents an emerging approach to genomic approaches by
testing treatment options directly on patient-derived models. Current assays, including the …