[HTML][HTML] Spondyloarthritis and the human leukocyte antigen (HLA)-B* 27 connection

CG Kavadichanda, J Geng, SN Bulusu… - Frontiers in …, 2021 - frontiersin.org
Heritability of Spondyloarthritis (SpA) is highlighted by several familial studies and a high
association with the presence of human leukocyte antigen (HLA)-B* 27. Though it has been …

Effect of mechanical stress on magnetic resonance imaging of the sacroiliac joints: assessment of military recruits by magnetic resonance imaging study

G Varkas, M de Hooge, T Renson, S De Mits… - …, 2018 - academic.oup.com
Objective To assess the baseline condition of the SI joints (SIJs) in healthy individuals
without symptoms of back pain and to study the effect of mechanical stress caused by …

[HTML][HTML] Psoriatic arthritis: what is happening at the joint?

J Belasco, N Wei - Rheumatology and Therapy, 2019 - Springer
Psoriatic arthritis (PsA) is a heterogeneous and inflammatory disease with diverse clinical
manifestations, including psoriasis, nail psoriasis, peripheral joint disease, axial joint …

Unexpected connections of the IL-23/IL-17 and IL-4/IL-13 cytokine axes in inflammatory arthritis and enthesitis

C Bridgewood, D Newton, N Bragazzi… - Seminars in …, 2021 - Elsevier
Abstract The IL-23/IL-17 cytokine axis is related to spondyloarthropathy (SpA) pattern
diseases that target the skin, eye, gut and joints. These share overlapping target tissues with …

Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression

G Herrero-Beaumont, S Perez-Baos… - Biochemical …, 2019 - Elsevier
Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degradation,
osteophyte formation, subchondral bone sclerosis, and synovitis. Systemic factors such as …

Lifestyle factors may modify the effect of disease activity on radiographic progression in patients with ankylosing spondylitis: a longitudinal analysis

S Ramiro, R Landewé, A van Tubergen, A Boonen… - RMD open, 2015 - rmdopen.bmj.com
Objectives To investigate the complex relationship between inflammation, mechanical stress
and radiographic progression in patients with ankylosing spondylitis (AS), using job type as …

Transition phase towards psoriatic arthritis: clinical and ultrasonographic characterisation of psoriatic arthralgia

A Zabotti, DG McGonagle, I Giovannini, E Errichetti… - RMD open, 2019 - rmdopen.bmj.com
Objective Non-specific musculoskeletal pain is common in subjects destined to develop
psoriatic arthritis (PsA). We evaluated psoriatic patients with arthralgia (PsOAr) compared …

Body mass index and the risk of rheumatic disease: linear and nonlinear Mendelian randomization analyses

T Karlsson, F Hadizadeh… - Arthritis & …, 2023 - Wiley Online Library
Objective Although the association between obesity and risk of rheumatic disease is well
established, the precise causal relation has not been conclusively proven. Here, we …

CXCL12/CXCR4-Rac1–mediated migration of osteogenic precursor cells contributes to pathological new bone formation in ankylosing spondylitis

H Cui, Z Li, S Chen, X Li, D Chen, J Wang, Z Li… - Science …, 2022 - science.org
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by inflammatory
back pain and spinal ankylosis due to pathological new bone formation. Here, we identified …

The role of the gut and microbes in the pathogenesis of spondyloarthritis

M Asquith, D Elewaut, P Lin, JT Rosenbaum - Best practice & research …, 2014 - Elsevier
The intestinal microbiota is firmly implicated not only in the pathogenesis of inflammatory
bowel disease (IBD) but increasingly also in the development of inflammation at …