The autonomic nervous system and hypertension

G Mancia, G Grassi - Circulation research, 2014 - Am Heart Assoc
Physiological studies have long documented the key role played by the autonomic nervous
system in modulating cardiovascular functions and in controlling blood pressure values …

Pathogenesis of hypertension

S Oparil, MA Zaman, DA Calhoun - Annals of internal medicine, 2003 - acpjournals.org
Increased recognition of specific causes of hypertension may lead to therapies that address
specific pathophysiologic mechanisms and cause fewer adverse effects. Research to …

Sympathetic activation in the pathogenesis of hypertension and progression of organ damage

G Mancia, G Grassi, C Giannattasio, G Seravalle - Hypertension, 1999 - Am Heart Assoc
Although animal models of hypertension have clearly shown that high blood pressure is
associated with and is probably caused by an increase in sympathetic cardiovascular …

Assessment of sympathetic cardiovascular drive in human hypertension: achievements and perspectives

G Grassi - Hypertension, 2009 - Am Heart Assoc
Methodological refinements in the assessment of human sympathetic cardiovascular drive
have allowed throughout the years to better define the role of the sympathetic nervous …

How to assess sympathetic activity in humans

G Grassi, M Esler - Journal of hypertension, 1999 - journals.lww.com
Sympathetic factors play a central role not only in cardiovascular homeostatic control but
also in the pathogenesis and/or in the progression of several cardiovascular diseases, such …

Autonomic imbalance, hypertension, and cardiovascular risk

RD Brook, S Julius - American journal of hypertension, 2000 - academic.oup.com
It is clear from many large randomized trials and from the metaanalyses published in the
early 1990s1, 2 that medication treatment of hypertension can be fully protective in reducing …

Cortical modulation of thecardiovascular system

AJM Verberne, NC OWENS - Progress in neurobiology, 1998 - Elsevier
Cortical modulation of central cardiovascular control mechanisms has been recognized for
many decades. However, it is only recently that the mechanisms underlying cortical …

Molecular targets of antihypertensive peptides: understanding the mechanisms of action based on the pathophysiology of hypertension

K Majumder, J Wu - International journal of molecular sciences, 2014 - mdpi.com
There is growing interest in using functional foods or nutraceuticals for the prevention and
treatment of hypertension or high blood pressure. Although numerous preventive and …

Sympathetic neural activity in hypertension and related diseases

G Grassi - American journal of hypertension, 2010 - academic.oup.com
Background Several hemodynamic variables, such as blood pressure, vascular resistance,
cardiac output, and heart rate, are regulated, among others, by sympathetic cardiovascular …

Impaired autonomic nervous system-microbiome circuit in hypertension: a premise for hypertension therapy

J Zubcevic, EM Richards, T Yang, S Kim… - Circulation …, 2019 - Am Heart Assoc
Hypertension affects an estimated 103 million Americans, yet gaps in knowledge continue to
limit its successful management. Rapidly emerging evidence is linking gut dysbiosis to many …