Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and
associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration …

Psoriasis is a chronic inflammatory skin disease resulting from genetic, epigenetic,
environmental, and lifestyle factors. To date, several immunopathogenic mechanisms of …

Background Dupilumab is an IL-4 receptor α mAb inhibiting signaling of IL-4 and IL-13, key
drivers of type 2–driven inflammation, as demonstrated by its efficacy in patients with …

Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Background Tildrakizumab is a high-affinity, humanised, IgG1 κ antibody targeting
interleukin 23 p19 that represents an evolving treatment strategy in chronic plaque psoriasis …

Evidence has shown that gut microbiome plays a role in modulating the development of
diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The …

The skin is the front line of defense against insult and injury and contains many epidermal
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The …

Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been
profoundly revised following recent advances in the understanding of its pathophysiology. In …

Background: Psoriasis is a common, chronic inflammatory skin disorder, which can
significantly impact quality of life. Despite major breakthroughs in our understanding of the …

Over the past three decades, a considerable body of evidence has highlighted T cells as
pivotal culprits in the pathogenesis of psoriasis. This includes the association of psoriasis …