As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …

Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the
elderly individuals. Clinically, patients initially present with short-term memory loss …

A diagnosis of dementia is devastating at any age but diagnosis in younger patients
presents a particular challenge. The differential diagnosis is broad as late presentation of …

Protein homeostasis or proteostasis is an essential balance of cellular protein levels
mediated through an extensive network of biochemical pathways that regulate different …

Summary 25% of all people aged 55 years and older have a family history of dementia. For
most, the family history is due to genetically complex disease, where many genetic …

Background The causes of phenotypic heterogeneity in familial Alzheimer's disease with
autosomal dominant inheritance are not well understood. We aimed to characterise clinical …

Alzheimer disease is the most common cause of dementia. It occurs worldwide and affects
all ethnic groups. The incidence of Alzheimer disease is increasing due, in part, to increased …

Early-onset familial Alzheimer's disease (EOFAD) is a condition characterized by early onset
dementia (age at onset< 65 years) and a positive family history for dementia. To date, 230 …

Alzheimer disease is the most common cause of dementia and represents a major public
health problem. The neuropathologic findings of amyloid-β plaques and tau containing …