Mutational landscape of chronic myeloid leukemia: More than a single oncogene leukemia
S Adnan-Awad, M Kankainen, S Mustjoki - Leukemia & lymphoma, 2021 - Taylor & Francis
The BCR-ABL1 fusion gene, which causes aberrant kinase activity and uncontrolled cell
proliferation, is the hallmark of chronic myeloid leukemia (CML). The development of …
proliferation, is the hallmark of chronic myeloid leukemia (CML). The development of …
Exosomes and Extracellular Vesicles in Myeloid Neoplasia: The Multiple and Complex Roles Played by These “Magic Bullets”
S Bernardi, M Farina - Biology, 2021 - mdpi.com
Simple Summary Extracellular vesicles (EVs) are released by the majority of cell types and
can be isolated from both cell cultures and body fluids. They are involved in cell-to-cell …
can be isolated from both cell cultures and body fluids. They are involved in cell-to-cell …
[HTML][HTML] A review on the therapeutic role of TKIs in case of CML in combination with epigenetic drugs
M Amir, S Javed - Frontiers in genetics, 2021 - frontiersin.org
Chronic myeloid leukemia is a malignancy of bone marrow that affects white blood cells.
There is strong evidence that disease progression, treatment responses, and overall clinical …
There is strong evidence that disease progression, treatment responses, and overall clinical …
[HTML][HTML] The Activity of Novel BCR-ABL Small-Molecule Degraders Containing Pyrimidine Rings and Their Role in Overcoming Drug Resistance
X Zhang, L Tu, H Chai, Z Li, Y Fu, X Zheng… - Journal of …, 2022 - hindawi.com
Inducing protein degradation by proteolysis-targeting chimeras (PROTACs) has gained
tremendous momentum in the field for its promise in the discovery and development of new …
tremendous momentum in the field for its promise in the discovery and development of new …
Understanding and monitoring chronic myeloid leukemia blast crisis: how to better manage patients
L Wang, L Li, R Chen, X Huang, X Ye - Cancer Management and …, 2021 - Taylor & Francis
Chronic myeloid leukemia (CML) is triggered primarily by the t (9; 22)(q34. 13; q11. 23)
translocation. This reciprocal chromosomal translocation leads to the formation of the BCR …
translocation. This reciprocal chromosomal translocation leads to the formation of the BCR …
De‐escalation or discontinuation of tyrosine kinase inhibitor in patients with chronic myeloid leukemia: A multicentral, open‐label, prospective trial in China
J Luo, X Du, J Lou, J Wu, L Ma, J Huang, L Wang… - …, 2022 - Wiley Online Library
Background: Long‐term treatment‐free remission (TFR) represents a new goal for chronic
myeloid leukemia (CML). Optimizing dose of tyrosine kinase inhibitors (TKIs) in the CML …
myeloid leukemia (CML). Optimizing dose of tyrosine kinase inhibitors (TKIs) in the CML …
Development of BCR-ABL1 transgenic zebrafish model reproducing chronic myeloid leukemia (CML) like-disease and providing a new insight into CML mechanisms
Zebrafish has proven to be a versatile and reliable experimental in vivo tool to study human
hematopoiesis and model hematological malignancies. Transgenic technologies enable the …
hematopoiesis and model hematological malignancies. Transgenic technologies enable the …
Cytotoxic marine alkaloid 3, 10-dibromofascaplysin induces apoptosis and synergizes with cytarabine resulting in leukemia cell death
P Spirin, E Shyrokova, T Lebedev, E Vagapova… - Marine Drugs, 2021 - mdpi.com
Myeloid leukemia is a hematologic neoplasia characterized by a clonal proliferation of
hematopoietic stem cell progenitors. Patient prognosis varies depending on the subtype of …
hematopoietic stem cell progenitors. Patient prognosis varies depending on the subtype of …
[HTML][HTML] Utilization of CRISPR-mediated tools for studying functional genomics in hematological malignancies: an overview on the current perspectives, challenges …
M Solayappan, A Azlan, KZ Khor, MY Yik… - Frontiers in …, 2022 - frontiersin.org
Haematologic malignancies (HM) are a group of neoplastic disease that are usually
heterogenous in nature due to the complex underlying genetic aberrations in which …
heterogenous in nature due to the complex underlying genetic aberrations in which …
[HTML][HTML] Chronic myeloid leukemia and pregnancy: when dreams meet reality. State of the art, management and outcome of 41 cases, nilotinib placental transfer
E Abruzzese, S Aureli, F Bondanini… - Journal of Clinical …, 2022 - mdpi.com
The overwhelming success of tyrosine kinase inhibitor (TKI) therapy in chronic myeloid
leukemia (CML) patients has opened a discussion among medical practitioners and the lay …
leukemia (CML) patients has opened a discussion among medical practitioners and the lay …