Despite its debilitating symptoms, the pathophysiology of bipolar disorder (BD) remains
unclear. One consistently compelling finding, however, has been the presence of oxidative …

BackgroundA reliable biomarker signature for bipolar disorder sensitive to illness phase
would be of considerable clinical benefit. Among circulating blood-derived markers there …

Context Accumulating evidence suggests that mitochondrial dysfunction and oxidative stress
contribute to the pathogenesis of bipolar disorder and schizophrenia. It remains unclear …

BACKGROUND: Oxidative stress is thought to mediate neuropathological processes of a
number of neuropsychiatric disorders and recent data suggest that oxidative stress may be …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

The pathophysiology of psychiatric diseases, including depression, anxiety, schizophrenia
and autism, is far from being fully elucidated. In recent years, a potential role of the oxidative …

Background: Glutathione is an endogenous antioxidant and has a ubiquitous role in many of
the body's defences. Treatment with N-acetylcysteine (NAC) has been shown to increase …

BACKGROUND: Treatment-resistant subthreshold depression is a major problem in the
management of bipolar disorder. Both depression and bipolar disorder are complicated by …

J. Neurochem.(2012) 120, 644–659. Abstract S100B is a calcium‐binding protein
concentrated in glial cells, although it has also been detected in definite extra‐neural cell …

Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs …