The radioimmunoassay of cyclic nucleotides has brought about a profound change in our
vision of the biological processes in which these molecules are involved. The basic …

By employing a combination of highly sensitive radioimmunoassays and histochemical
techniques, an in vivo time course of cGMP levels has been determined in the outer …

The final goal in studying photoreceptors is to find out how light produces an electric current
across the plasma membrane which in turn generates the visual message. The properties of …

The absorption of light by the vertebrate rod outer segment (ROS) results in a change in the
polarization of the plasma membrane of the cell. This change in charge distribution is due to …

The rod photoreceptors of the vertebrate retina are both structurally and functionally
polarized. At one end of the cells, the outer segment, absorption of light by the photopigment …

The retina is a region of the central nervous system that is highly specialized for the
reception of light and the transmission of encoded visual information to the brain. It develops …

The increase in sensitivity of frog photoreceptors after illumination,“hypersensitivity”, was
studied by recording fast-PIII responses of the isolated bull frog retina superfused with …

Overview This chapter summarizes cyclic nucleotide involvement in the eye. While all areas
of the eye are discussed, greatest emphasis will be on the retina. The levels of retinal cyclic …

The suggestion of Bairati and Orzalesi (1) that the dense bodies in the pigment epithelium
resembled fragments of outer segment material was experimentally established in the …

A procedure for the immunocytochemical localization of cGMP in the goldfish retina is
described. The procedure is then used to evaluate the presence of cGMP in cone color …