Simple Summary Colorectal cancer is a leading cause of cancer mortality, and its incidence
is rapidly increasing worldwide. Colorectal cancer is considered a single entity based on …

Objective Numerous scattered case studies continue to demonstrate a strong correlation
between acquired KRAS mutations and epidermal growth factor receptor-tyrosine kinase …

Cancer remains the leading cause of global mortality, prompting a paradigm shift in its
treatment and outcomes with the advent of targeted therapies. Among the most prevalent …

Background Surgical resection followed by indicated adjuvant therapy offers potential
curative treatment in colonic adenocarcinoma. Beyond the well-established seed and soil …

Stage 4 colon cancer (CC) presents a significant global health challenge due to its poor
prognosis and limited treatment options. Tetraspanins, the transmembrane proteins involved …

Simple Summary Imaging biomarkers that permit non-invasive, real-time monitoring of the
tumor microenvironment could serve a critical role to facilitate treatment personalization …

Background Recently, consensus molecular subtypes (CMSs) have been proposed as a
robust transcriptome-based classification system for colorectal cancer (CRC). Tetraspanins …

The expression of the protein Mesothelin (MSLN) is highly variable in several malignancies
including colorectal cancer (CRC) and high levels are associated with aggressive …

Objectives Biobanks play an important role in advancing cancer research, yet concerns
persist regarding the molecular integrity of long-term stored samples. This study assessed …

Background Preoperative neoadjuvant chemoradiotherapy (nCRT) followed by total
mesorectal excision (TME) is a common approach for treating patients with locally advanced …