Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has
both genetic and environmental risk factors, resulting in impaired glucose homeostasis …

The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we
assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate …

Three-dimensional (3D) multicellular organoids recapitulate the native complexities of
human tissue better than traditional cellular monolayers. As organoids are insufficiently …

The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here,
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …

Stem cell-derived β (SC-β) cells could provide unlimited human β cells toward a curative
diabetes treatment. Differentiation of SC-β cells yields transplantable islets that secrete …

Glucagon-like peptide-1 receptor (GLP1R) agonists and dipeptidyl peptidase 4 inhibitors are
widely prescribed diabetes drugs due to their ability to stimulate insulin secretion from …

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …