[HTML][HTML] Applied machine learning as a driver for polymeric biomaterials design

SM McDonald, EK Augustine, Q Lanners… - Nature …, 2023 - nature.com
Polymers are ubiquitous to almost every aspect of modern society and their use in medical
products is similarly pervasive. Despite this, the diversity in commercial polymers used in …

Molecular bases for temperature sensitivity in supramolecular assemblies and their applications as thermoresponsive soft materials

H Liu, T Prachyathipsakul, TM Koyasseril-Yehiya… - Materials …, 2022 - pubs.rsc.org
Thermoresponsive supramolecular assemblies have been extensively explored in diverse
formats, from injectable hydrogels to nanoscale carriers, for a variety of applications …

Materials design of highly branched bottlebrush polymers at the intersection of modeling, synthesis, processing, and characterization

T Pan, S Dutta, Y Kamble, BB Patel… - Chemistry of …, 2022 - ACS Publications
Highly branched “bottlebrush” polymers are a class of macromolecules characterized by
side chains that are densely grafted from a backbone that is typically linear. Their unique …

Cationic bottlebrush polymers outperform linear polycation analogues for pDNA delivery and gene expression

RJ Dalal, R Kumar, M Ohnsorg, M Brown… - ACS Macro …, 2021 - ACS Publications
Cationic polymer vehicles have emerged as promising platforms for nucleic acid delivery
because of their scalability, biocompatibility, and chemical versatility. Advancements in …

Divergent synthesis of graft and branched copolymers through spatially controlled photopolymerization in flow reactors

N Corrigan, FJ Trujillo, J Xu, G Moad, CJ Hawker… - …, 2021 - ACS Publications
In this work, we demonstrate the controlled synthesis of graft and branched copolymers
using one-pot (batch) or one-pass (flow) processes without intermediate purification. The …

Structural engineering of star block biodegradable polymer unimolecular micelles for drug delivery in cancer cells

U Pranav, M Malhotra, S Pathan… - … Biomaterials Science & …, 2022 - ACS Publications
The present investigation reports the structural engineering of biodegradable star block
polycaprolactone (PCL) to tailor-make aggregated micelles and unimolecular micelles to …

From macromonomers to bottlebrush copolymers with sequence control: synthesis, properties, and applications

KH Kim, J Nam, J Choi, M Seo, J Bang - Polymer Chemistry, 2022 - pubs.rsc.org
Bottlebrush polymers (BBPs) are a type of comb-like macromolecule with densely grafted
polymeric sidechains attached to the polymer backbones, and many intriguing properties …

Tuning the hydrophilic–hydrophobic balance of molecular polymer bottlebrushes enhances their tumor homing properties

P Ramamurthi, Z Zhao, E Burke… - Advanced …, 2022 - Wiley Online Library
Nanoparticle (NP)‐based drug delivery systems are promising in anticancer therapy,
capable of delivering cargo with superior selectivity and achieving enhanced tumor …

Experimental validation on average conformation of a comblike polystyrene library in dilute solutions: universal scaling laws and abnormal SEC elution behavior

X Pan, M Ding, L Li - Macromolecules, 2021 - ACS Publications
In this work, a sample library of well-defined comblike polystyrenes (PS) has been prepared
for the study of average conformation in dilute solutions. The dependences of radius of …

[HTML][HTML] Water-soluble polyphosphonate-based bottlebrush copolymers via aqueous ring-opening metathesis polymerization

DA Resendiz-Lara, S Azhdari, H Gojzewski… - Chemical …, 2023 - pubs.rsc.org
Ring-opening metathesis polymerization (ROMP) is a versatile method for synthesizing
complex macromolecules from various functional monomers. In this work, we report the …