Sažetak The accurate prediction of solubility of drugs is still problematic. It was thought for a
long time that shortfalls had been due the lack of high-quality solubility data from the …

An early prediction of physicochemical properties is highly desirable during drug discovery
to find out a viable lead candidate. Although there are several methods available to …

Synthetic ion transporters have attracted tremendous attention for their therapeutic potential
against various ion-transport-related diseases, including cancer. Inspired by the structure …

The coformulated lopinavir/ritonavir significantly reduces quinine concentration in healthy
volunteers due to potential drug–drug interactions (DDIs). However, DDI information in …

Abstract The Biopharmaceutics Classification System (BCS) defines the solubility
characteristics of an active pharmaceutical substance based on its dose–solubility ratio: for …

The range of applications for aptamers, small oligonucleotide-based receptors binding to
their targets with high specificity and affinity, has been steadily expanding. Our …

Defects in the active layer of reverse osmosis (RO) membranes play a crucial role in the
passage of virus particles and microbial surrogates through the membrane systems. Prior …

Perampanel is a novel antiepileptic drug used in paediatric patients. Existing methods that
determine serum perampanel are of limited practicability. We developed a novel capillary …

Background Malaria is a complex disease and main community health problem in Africa and
the top leading cause of outpatient visits, admissions, and deaths in Ethiopia. Its effective …

The cocaine aptamer was later found to bind quinine with an even higher affinity. In this
work, we used a fluorescently labeled aptamer named MN4 to study its adsorption by gold …