The antimalarial drug quinine (QUN) has poor aqueous solubility and belongs to
Biopharmaceutical Classification System (BCS) Class-II. We report 12 novel molecular salts …

Quinine‐and cryptolepine‐based antimalarials serve as valuable alternatives to artemisinin‐
based combination therapies (ACTs) in Ghana. Their use, however, is associated with …

Despite having adequate solubility properties, bioequivalence (BE) studies performed on
immediate release formulations containing BCS1/3 drugs occasionally fail. By systematically …

生物药剂学分类系统将药物按溶解度和渗透性分为4 类, 在指导新药研发和剂型设计,
预测药物体内体外相关性, 进行生物豁免研究等方面发挥了非常重要的作用 …

The co-formulated lopinavir/ritonavir significantly reduces quinine concentration in healthy
volunteers due to potential drug-drug interactions (DDIs). However, DDIs information in …

Patients with cerebral malaria with polymorphic Cytochrome P450 2C19 (CYP2C19)
genotypes who receive concurrent treatment with quinine are at risk of inadequate or toxic …

Solubility and permeability are recognized as key parameters governing drug intestinal
absorption and represent the basis for biopharmaceutics drug classification. The …

Abstract Resumen Context: The fight against malaria is limited by development of resistance
of Plasmodium to medication. This has led to an urgent search for alternative medicinal …

A rapid, efficient, and precise RP-HPLC protocol has been developed to quantify
dihydroquinine content in quinine sulfate pharmaceutical dosage form accurately. This …

Using diperoxysebacic acid as an example, it was shown the interaction of
diperoxycarboxylic acids with quinine alkaloid in an aqueous medium by kinetics method …